Chemistry, Biochemistry Concentration (M.S.) - Graduate - 2012 University Catalog

You are viewing the 2012 University Catalog. Please see the newest version of the University Catalog for the most current version of this program's requirements.

The Chemistry and Biochemistry Department offers two options for the Master's degree: the Master of Science in Chemistry and the Master of Science in Chemistry with Concentration in Biochemistry. The courses offered include advanced courses in all major areas of Chemistry and Biochemistry, and include a number of highly specialized instrumentation courses as well as individual research opportunities. Laboratories are housed in both Richardson Hall and Science Hall. Students may selectively take one or two courses as non-degree students, to increase their professional competence in a particular area of Chemistry or Biochemistry, or may elect to enroll in one of the Master of Science programs, as outlined below.

The Biochemistry concentration provides a flexible program of study for those students who wish to emphasize Biochemistry and related areas in their Master's degree. Those working in research in the pharmaceutical industry or interested in doing so, and individuals interested in pursuing an M.D. or a Ph.D. in Biochemistry or a related area would benefit from this program. It is most suited to students with an undergraduate degree in Biochemistry but is also suitable for students with a major in Chemistry who wish to broaden their knowledge in Biochemistry. As indicated above, students with other backgrounds can also be accommodated.

ADMISSIONS

The minimum requirements for admission to the Graduate School are essential for admission to one of the graduate programs in the Department of Chemistry and Biochemistry. When a student has been admitted, the Graduate Program Coordinator for Chemistry and Biochemistry will evaluate the background in chemistry, biochemistry, other sciences and mathematics, and a specific program will be designed. An entering student should present at least twenty-four semester hours of undergraduate chemistry credits. In consultation with the Graduate Program Coordinator, a program may be designed for a student with insufficient background to include prerequisites. Candidates for the Master's degree should seek the guidance of the Graduate Program Coordinator in selecting electives and in fulfilling the research option.


CHEMISTRY w/CONC:Biochemistry

Complete 32 semester hours including the following 4 requirement(s):

  1. CHEMISTRY/BIOCHEMISTRY COURSES

    Complete 21 semester hours from the following:

    1. 12 semester hours-21 semester hours from the following list.

      CHEM 525 Bioinorganic Chemistry (3 hours lecture) 3
      CHEM 533 Biosynthesis of Natural Products (3 hours lecture) 3
      CHEM 538 Drug Design in Medicinal Chemistry (3 hours lecture) 3
      CHEM 570 Selected Topics in Advanced Biochemistry (3 hours lecture) 3
      CHEM 574 Protein Structure (3 hours lecture) 3
      CHEM 575 Enzyme Kinetics and Mechanisms (3 hours lecture) 3
      CHEM 576 Lipid Biochemistry (3 hours lecture) 3
      CHEM 577 Nucleic Acid Biochemistry (3 hours lecture) 3
      CHEM 578 Biochemistry Laboratory Techniques (2 hours lecture, 3 hours lab) 3
    2. Up to 9 semester hours from the following list (not already completed in part A).

      CHEM 501 Teaching Chemistry in the Secondary School (3 hours lecture) 3
      CHEM 510 Hazardous Materials Management (3 hours lecture) 3
      CHEM 521 Advanced Topics in Inorganic Chemistry (3 hours lecture) 3
      CHEM 525 Bioinorganic Chemistry (3 hours lecture) 3
      CHEM 531 Advanced Topics in Organic Chemistry (3 hours lecture) 3
      CHEM 532 Organic Synthesis (3 hours lecture) 3
      CHEM 533 Biosynthesis of Natural Products (3 hours lecture) 3
      CHEM 534 Chromatographic Methods: Theory and Practice (3 hours lecture) 3
      CHEM 536 Nuclear Magnetic Resonance: Theory and Practice (3 hours lecture) 3
      CHEM 538 Drug Design in Medicinal Chemistry (3 hours lecture) 3
      CHEM 540 Chemical Thermodynamics (3 hours lecture) 3
      CHEM 542 Theoretical Physical Chemistry (3 hours lecture) 3
      CHEM 544 Electrochemistry (3 hours lecture) 3
      CHEM 546 Chemical Spectroscopy (3 hours lecture) 3
      CHEM 548 Chemical Kinetics (3 hours lecture) 3
      CHEM 550 Organometallic Chemistry (3 hours lecture) 3
      CHEM 570 Selected Topics in Advanced Biochemistry (3 hours lecture) 3
      CHEM 574 Protein Structure (3 hours lecture) 3
      CHEM 575 Enzyme Kinetics and Mechanisms (3 hours lecture) 3
      CHEM 576 Lipid Biochemistry (3 hours lecture) 3
      CHEM 577 Nucleic Acid Biochemistry (3 hours lecture) 3
      CHEM 578 Biochemistry Laboratory Techniques (2 hours lecture, 3 hours lab) 3
      CHEM 579 Biomolecular Assay Development (2 hours lecture, 3 hours lab) 3
      CHEM 582 Biochemical Pharmacology (3 hours lecture) 3
      CHEM 590 Selected Topics-Advanced Chemistry (3 hours lecture) 3
      CHEM 595 Graduate Research 1-3
      CHEM 599 Graduate Literature Search in Chemistry 2
  2. RESEARCH OPTIONS

    Complete 1 of the following options:

    1. GRADUATE LITERATURE SEARCH

      Complete for 2 semester hours. A Biochemistry topic must be selected and approved by advisor.

      CHEM 599 Graduate Literature Search in Chemistry 2
    2. RESEARCH & THESIS

      1. Complete the following for 3 semester hours:

        CHEM 595 Graduate Research 1-3
      2. Complete 2 Thesis requirement(s):

        1. Complete .

          CHEM 698 Master's Thesis 3
        2. Submit the completed Thesis original and one copy to the Graduate Office. See Thesis Guidelines for details.

  3. ELECTIVES

    Complete 9 semester hours (or 5 semester hours if completing Thesis) of Chem/Biochem/ Allied Science electives with written approval from advisor.

    BIOL 512 Topics in Modern Genetics (3 hours lecture) 3
    BIOL 547 Molecular Biology I (3 hours lecture) 3
    BIOL 548 Molecular Biology II (3 hours lecture, 3 hours lab) 4
    BIOL 598 Selected Techniques in Molecular Biology (1 hour lecture, 2 hours lab) 1.5
  4. COMPREHENSIVE EXAMINATION

    Successfully complete the Comprehensive Examination.


Course Descriptions:

BIOL512: Topics in Modern Genetics (3 hours lecture)

Seminar course. Selected topics from current development in genetic research, including chromosome and gene fine structure, extra chromosomal genetic elements, genetic engineering, and aspects of biomedical genetic research. May be repeated once for a maximum of 6.0 credits as long as the topic is different. 3 sh.

Prerequisites: Undergraduate course in genetics.

BIOL547: Molecular Biology I (3 hours lecture)

Central concepts at the cellular level will be emphasized. Contemporary viewpoints in the areas of biomolecules, energy yielding and energy requiring processes and transfer of genetic information. 3 sh.

Prerequisites: Cell biology, and one year organic chemistry.

BIOL548: Molecular Biology II (3 hours lecture, 3 hours lab)

Central concepts at the cellular level will be emphasized. Contemporary viewpoints in the areas of biomolecules, energy yielding and energy requiring processes and transfer of genetic information. The laboratory will deal with up-to-date investigative procedures via selected experiments. 4 sh.

Prerequisites: BIOL 547.

BIOL598: Selected Techniques in Molecular Biology (1 hour lecture, 2 hours lab)

A laboratory course that trains students in advanced techniques in molecular biology. Students will learn how to perform a specific technique as well as learning the theory behind the technique. May be repeated three times for a maximum of 6.0 credits. 1.5 sh.

Prerequisites: Undergraduate or graduate molecular biology courses or equivalent and permission of instructor.

CHEM501: Teaching Chemistry in the Secondary School (3 hours lecture)

Study of objectives, recent trends, methods of presentation, courses of study, lesson planning, instructional aids, and subject matter of high school chemistry. 3 sh.

Prerequisites: 16 semester hours in chemistry.

CHEM510: Hazardous Materials Management (3 hours lecture)

Exploration of the physical and chemical characteristics of hazardous chemicals, hazardous waste, and mixed waste materials. Their sources, handling, transportation, storage, disposal, and regulation. 3 sh.

Prerequisites: CHEM 230 or equivalent. For majors in College of Sciences and Mathematics or instructor's permission.

CHEM521: Advanced Topics in Inorganic Chemistry (3 hours lecture)

Current theories of inorganic structure, reactions and properties. May be repeated twice for a maximum of 9.0 credits as long as the topic is different. 3 sh.

Prerequisites: One year of physical chemistry.

CHEM525: Bioinorganic Chemistry (3 hours lecture)

Exploration of the vital roles that metal atoms play in biochemical processes. Transition metal interactions with proteins will be emphasized. The course will focus on the structural, regulatory, catalytic, transport, and oxidation-reduction functions of metal containing biomolecules. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II) or instructor's permission.

CHEM531: Advanced Topics in Organic Chemistry (3 hours lecture)

Modern theories of organic chemistry with emphasis on electronic theory and reaction mechanisms. May be repeated three times for a maximum of 12.0 credits as long as the topic is different. 3 sh.

Prerequisites: CHEM 430 (Advanced Organic Chemistry).

CHEM532: Organic Synthesis (3 hours lecture)

Detailed study of the art, methods, and the philosophy of organic synthesis beginning with a review of classical and modern synthetic methods, followed by the planning theory of synthesis and culminating in a study of elegant syntheses in the literature. 3 sh.

Prerequisites: CHEM 430 (Advanced Organic Chemistry).

CHEM533: Biosynthesis of Natural Products (3 hours lecture)

A study of natural products with emphasis on the biosynthesis of primary and secondary metabolites. 3 sh.

Prerequisites: CHEM 430 (Advanced Organic Chemistry) or equivalent.

CHEM534: Chromatographic Methods: Theory and Practice (3 hours lecture)

A combined lecture/hands-on course in the theory and practice of chromatography; including GC, HPLC, GC-MS, GPC, and SFC, as well as computerized instrument control, data acquistion, and processing. 3 sh.

Prerequisites: CHEM 310 (Analytical Chemistry) and 311 (Instrumental Analysis) or equivalents.

CHEM536: Nuclear Magnetic Resonance: Theory and Practice (3 hours lecture)

A combination lecture/hands-on course utilizing the department's FT-NMR's to provide students with theoretical background and practical experience in modern 1-D and 2-D FT-NMR. 3 sh.

Prerequisites: CHEM 310 (Analytical Chemistry) and 311 (Instrumental Analysis) or equivalents.

CHEM538: Drug Design in Medicinal Chemistry (3 hours lecture)

A comprehensive course covering the design and action of pharmaceutical agents. 3 sh.

Prerequisites: Matriculation into the graduate program or permission of instructor.

CHEM540: Chemical Thermodynamics (3 hours lecture)

In-depth study of classical thermodynamics. Development of thermodynamic functions describing chemical systems in equilibrium, with emphasis on systems of variable composition. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II) or instructor's permission.

CHEM542: Theoretical Physical Chemistry (3 hours lecture)

Theoretical development of quantum mechanics and statistical mechanics as applied to chemistry. Application of theoretical procedures to atomic and molecular structure and bonding. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II) and MATH 420 (Differential Equations).

CHEM544: Electrochemistry (3 hours lecture)

Principles and application of electrochemistry, relationship of electrochemical principles to classical thermodynamics, and practical applications of electrochemistry. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II).

CHEM546: Chemical Spectroscopy (3 hours lecture)

Introduction to the theory of molecular spectroscopy. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II).

CHEM548: Chemical Kinetics (3 hours lecture)

Kinetics in its role of elucidating reaction mechanisms. Discussion of recent problems from the chemical literature including fast reactions and enzyme kinetics. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II).

CHEM550: Organometallic Chemistry (3 hours lecture)

The course will introduce students to organometallic chemistry, mainly involving transition metals, but also including some main group metals. The material covered will focus on the unique chemistry of these compounds and their uses in organic synthesis, material science, and as catalysts. 3 sh.

Prerequisites: CHEM 420 and CHEM 430 or equivalents.

CHEM570: Selected Topics in Advanced Biochemistry (3 hours lecture)

A detailed treatment of selected topics in biochemistry. Special emphasis upon recent developments. Protein structure, enzymology, metabolism, nucleic acid chemistry are examples of topics. This course may be repeated for credit indefinitely as long as the topic is different each time. 3 sh.

Prerequisites: CHEM 370 or instructor's permission.

CHEM574: Protein Structure (3 hours lecture)

Primary, secondary and tertiary structure of proteins, protein structural motifs and protein structural families. Globular proteins, DNA binding proteins, membrane proteins, signal transduction systems, immune system protein structure, methods used for determination of protein structure. 3 sh.

Prerequisites: One semester of introductory Biochemistry or similar background.

CHEM575: Enzyme Kinetics and Mechanisms (3 hours lecture)

The following properties of enzymes are considered: structure, specificity, catalytic power, mechanism of action, multienzyme complexes, kinetics, regulation, and multienzyme systems. 3 sh.

Prerequisites: CHEM 370 or equivalent.

CHEM576: Lipid Biochemistry (3 hours lecture)

Chemistry of plant and animal lipids, their occurrence, metabolism, and industrial uses. 3 sh.

Prerequisites: CHEM 370 or equivalent.

CHEM577: Nucleic Acid Biochemistry (3 hours lecture)

This course will present fundamental aspects of nucleic acid biochemistry including structure and biological function and will be organized according to a systematic consideration of techniques used in the study of nucleic acids. Current literature and key topics such as protein-DNA, protein-drug complexes and nucleic acid repair mechanisms will be considered. 3 sh.

Prerequisites: CHEM 370 or equivalent.

CHEM578: Biochemistry Laboratory Techniques (2 hours lecture, 3 hours lab)

Fundamental techniques used to isolate, characterize, and study nucleic acids, proteins, carbohydrates, and lipids. Theory and application of buffers, spectrophotometry, tissue fractionation, centrifugation, extraction, chromatographic separations, electrophoresis, radioactivity, enzyme purification and dinetics, enzymatic assays, NMR and MS structure determination. 3 sh.

Prerequisites: CHEM 370 or equivalent.

CHEM579: Biomolecular Assay Development (2 hours lecture, 3 hours lab)

This course will provide the student with hands-on experience of state of the art techniques used for drug discovery research in the pharmaceutical industry. These techniques include assay development for high throughput screening and molecular docking methods for lead discovery. Using these techniques will allow the student to understand the drug discovery process, which includes a dialogue between crystallographers, medicinal chemists, biochemists, and biologists. 3 sh.

Prerequisites: CHEM 370 or instructor's permission.

CHEM582: Biochemical Pharmacology (3 hours lecture)

How drugs interact with, and influence biochemical pathways relevant to disease in the whole organism. Topics covered in this course deal with a review of fundamental concepts in biochemisty relevant to drug discovery, the process of drug discovery and specific examples of drug interactions with biochemical pathways and how they impact human disease. 3 sh.

Prerequisites: CHEM 370 and CHEM 371.

CHEM590: Selected Topics-Advanced Chemistry (3 hours lecture)

An in-depth study of selected areas in either analytical, inorganic, organic or physical chemistry, with special emphasis upon recent developments in the field. May be repeated three times for a maximum of 12 credits as long as the topic is different each time. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II) or instructor's permission.

CHEM595: Graduate Research

Directed individual laboratory investigation under guidance of faculty advisor. May be elected once or twice, maximum credit allowed is 3 semester hours. 1 - 3 sh.

Prerequisites: Completion of 12 semester hours in this graduate program; instructor's permission.

CHEM599: Graduate Literature Search in Chemistry

An individual, non-experimental investigation utilizing the scientific literature. 2 sh.

Prerequisites: Completion of 12 semester hours in this graduate program.

CHEM698: Master's Thesis

Independent research project done under faculty advisement. Students must follow the MSU Thesis Guidelines, which may be obtained from the Graduate School. Students should take CHEM 699 if they don't complete CHEM 698 within the semester. 3 sh.

Prerequisites: Departmental approval.