Pharmaceutical Biochemistry (M.S.) - Graduate - 2015 University Catalog

The objective of this program is to provide students with the opportunity to obtain a Master of Science Degree in Pharmaceutical Biochemistry at Montclair State University. Graduates from this program will be prepared for careers in applied research or product development in the pharmaceutical industry and for work in management, inspection, sales, and service. Specifically these graduates will have the requisite skills in biochemistry, drug design and pharmacology to set them on a career path in the pharmaceutical industry.

This program is uniquely poised to meet these objectives by providing a core curriculum which closely parallels the drug discovery process followed within the Pharmaceutical Industry. The core curriculum provides training in the biochemical aspects of drug discovery, drug screening and medicinal chemistry technologies and pharmacological evaluation of new drug candidates.

This program will ideally be suited for students with a Bachelor’s degree in Biochemistry or Chemistry. The particular course of study will be developed on an individual basis for each student, so that students with a background in areas other than Biochemistry or Chemistry can be accommodated by including the necessary biochemical prerequisites before starting the core curriculum.


PHARMACEUTICAL BIOCHEMISTRY

Complete 32 semester hours including the following 3 requirement(s):

  1. CORE COURSES

    Complete 4 courses for 12 semester hours:

    CHEM 570 Advanced Biochemistry (3 hours lecture) 3
    CHEM 575 Enzyme Kinetics and Mechanisms (3 hours lecture) 3
    CHEM 579 Biomolecular Assay Development (2 hours lecture, 3 hours lab) 3
    CHEM 582 Biochemical Pharmacology (3 hours lecture) 3
  2. ELECTIVES AND RESEARCH

    Complete the following 2 requirement(s) for 20 semester hours:

    1. ELECTIVES

      Complete 18 semester hours (or 14 semester hours if completing Thesis) from the following:

      1.  

        CHEM 525 Bioinorganic Chemistry (3 hours lecture) 3
        CHEM 530 Advanced Organic Chemistry (3 hours lecture) 3
        CHEM 538 Drug Design in Medicinal Chemistry (3 hours lecture) 3
        CHEM 560 Advanced Analytical Chemistry (3 hours lecture) 3
        CHEM 574 Protein Structure (3 hours lecture) 3
        CHEM 577 Nucleic Acid Biochemistry (3 hours lecture) 3
        CHEM 578 Biochemistry Laboratory Techniques (2 hours lecture, 3 hours lab) 3
      2. 0 semester hours - 6 semester hours may be taken from:

        BIOL 505 Experimental Cell Culture (2 hours lecture, 2 hours lab) 3
        BIOL 512 Topics in Modern Genetics (3 hours lecture) 3
        BIOL 547 Molecular Biology I (3 hours lecture) 3
        BIOL 548 Molecular Biology II (3 hours lecture, 3 hours lab) 4
        BIOL 594 Signal Transduction (3 hours lecture) 3
        BIOL 598 Selected Techniques in Molecular Biology (1 hour lecture, 2 hours lab) 1.5
    2. RESEARCH OPTIONS

      Complete 1 of the following options:

      1. GRADUATE LITERATURE SEARCH

        Complete 2 courses for 2 semester hours (topic must be selected with and approved by advisor):

        1. Complete for 1 semester hours.

          CHEM 598 Graduate Literature Search (2 hours independent study) 1
        2. Complete for 1 semester hours.

          CHEM 599 Graduate Seminar (1 hour lecture) 1
      2. RESEARCH & THESIS

        1. Complete for 3 semester hours.

          CHEM 595 Graduate Research 1-3
        2. Complete 2 Thesis requirement(s):

          1. Complete for 3 semester hours.

            CHEM 698 Master's Thesis 3
          2. Submit the completed Thesis original and one copy to the Graduate Office. See Thesis Guidelines for details.

  3. CULMINATING EXPERIENCE

    Make a seminar presentation in conjunction with Research option. Graduate School must be notified when complete.


Course Descriptions:

BIOL505: Experimental Cell Culture (2 hours lecture, 2 hours lab)

This graduate course will provide theoretical and practical experience working on living cells. Provides understanding, observation, and hands-on experiences in tissue and organ culture techniques, primary cell culturing, cell differentiation, and techniques in toxicity and mutagenicity assays, plant callus and protopast experimentation. 3 sh.

Prerequisites: BIOL 380, or similar Genetics course with passing grade and a previous Microbiology course or experience.

BIOL512: Topics in Modern Genetics (3 hours lecture)

Seminar course. Selected topics from current development in genetic research, including chromosome and gene fine structure, extra chromosomal genetic elements, genetic engineering, and aspects of biomedical genetic research. May be repeated once for a maximum of 6.0 credits as long as the topic is different. 3 sh.

Prerequisites: Undergraduate course in genetics.

BIOL547: Molecular Biology I (3 hours lecture)

Central concepts at the cellular level will be emphasized. Contemporary viewpoints in the areas of biomolecules, energy yielding and energy requiring processes and transfer of genetic information. 3 sh.

Prerequisites: Cell biology, and one year organic chemistry.

BIOL548: Molecular Biology II (3 hours lecture, 3 hours lab)

Central concepts at the cellular level will be emphasized. Contemporary viewpoints in the areas of biomolecules, energy yielding and energy requiring processes and transfer of genetic information. The laboratory will deal with up-to-date investigative procedures via selected experiments. 4 sh.

Prerequisites: BIOL 547.

BIOL594: Signal Transduction (3 hours lecture)

This course will cover various aspects of cellular signaling from the plasma membrane to the nucleus. Topics will include specific signal transduction systems, methods for studying these systems and the results of these signaling events on cell division, cell differentiation and cell function. 3 sh.

Prerequisites: BIOL 547 or permission of instructor.

BIOL598: Selected Techniques in Molecular Biology (1 hour lecture, 2 hours lab)

A laboratory course that trains students in advanced techniques in molecular biology. Students will learn how to perform a specific technique as well as learning the theory behind the technique. May be repeated three times for a maximum of 6.0 credits. 1.5 sh.

Prerequisites: Undergraduate or graduate molecular biology courses or equivalent and permission of instructor.

CHEM525: Bioinorganic Chemistry (3 hours lecture)

Exploration of the vital roles that metal atoms play in biochemical processes. Transition metal interactions with proteins will be emphasized. The course will focus on the structural, regulatory, catalytic, transport, and oxidation-reduction functions of metal containing biomolecules. 3 sh.

Prerequisites: CHEM 341 (Physical Chemistry II) or instructor's permission.

CHEM530: Advanced Organic Chemistry (3 hours lecture)

Structure, reactivity and mechanisms in organic chemistry: Topics include bonding, stereochemistry, aromaticity, study of reaction mechanisms and reactive intermediates, linear free energy relationships, pericyclic reactions and organic photochemistry. Previous course CHEM 531 effective through Spring 2014. 3 sh.

Prerequisites: CHEM 430 or departmental approval.

CHEM538: Drug Design in Medicinal Chemistry (3 hours lecture)

A comprehensive course covering the design and action of pharmaceutical agents. 3 sh.

Prerequisites: Matriculation into the graduate program or permission of instructor.

CHEM560: Advanced Analytical Chemistry (3 hours lecture)

This course builds on existing knowledge of analytical chemistry to develop a deeper understanding of how quality and quantity of data, propagation of errors, and instrumentation and laboratory protocols affect the uncertainty in measurements. This will be tied into the relevance and importance of validation of equipment and protocols and standard laboratory practices, which are discussed in light of requirements from regulatory agencies. 3 sh.

Prerequisites: CHEM 310 and CHEM 311 or departmental approval.

CHEM570: Advanced Biochemistry (3 hours lecture)

Structure, function, and chemistry of proteins, carbohydrates, nucleic acids, and lipids. Analytical methods biochemists use to study metabolism, regulation, binding, and catalytic activity of biomolecules. 3 sh.

Prerequisites: CHEM 370 or instructor's permission.

CHEM574: Protein Structure (3 hours lecture)

Primary, secondary and tertiary structure of proteins, protein structural motifs and protein structural families. Globular proteins, DNA binding proteins, membrane proteins, signal transduction systems, immune system protein structure, methods used for determination of protein structure. 3 sh.

Prerequisites: One semester of introductory Biochemistry or similar background.

CHEM575: Enzyme Kinetics and Mechanisms (3 hours lecture)

The following properties of enzymes are considered: structure, specificity, catalytic power, mechanism of action, multienzyme complexes, kinetics, regulation, and multienzyme systems. 3 sh.

Prerequisites: CHEM 370 or equivalent.

CHEM577: Nucleic Acid Biochemistry (3 hours lecture)

This course will present fundamental aspects of nucleic acid biochemistry including structure and biological function and will be organized according to a systematic consideration of techniques used in the study of nucleic acids. Current literature and key topics such as protein-DNA, protein-drug complexes and nucleic acid repair mechanisms will be considered. 3 sh.

Prerequisites: CHEM 370 or equivalent.

CHEM578: Biochemistry Laboratory Techniques (2 hours lecture, 3 hours lab)

Fundamental techniques used to isolate, characterize, and study nucleic acids, proteins, carbohydrates, and lipids. Theory and application of buffers, spectrophotometry, tissue fractionation, centrifugation, extraction, chromatographic separations, electrophoresis, radioactivity, enzyme purification and dinetics, enzymatic assays, NMR and MS structure determination. 3 sh.

Prerequisites: CHEM 370 or equivalent.

CHEM579: Biomolecular Assay Development (2 hours lecture, 3 hours lab)

This course will provide the student with hands-on experience of state of the art techniques used for drug discovery research in the pharmaceutical industry. These techniques include assay development for high throughput screening and molecular docking methods for lead discovery. Using these techniques will allow the student to understand the drug discovery process, which includes a dialogue between crystallographers, medicinal chemists, biochemists, and biologists. 3 sh.

Prerequisites: CHEM 370 or instructor's permission.

CHEM582: Biochemical Pharmacology (3 hours lecture)

How drugs interact with, and influence biochemical pathways relevant to disease in the whole organism. Topics covered in this course deal with a review of fundamental concepts in biochemistry relevant to drug discovery, the process of drug discovery and specific examples of drug interactions with biochemical pathways and how they impact human disease. 3 sh.

Prerequisites: CHEM 370 and CHEM 371.

CHEM595: Graduate Research

Directed individual laboratory investigation under guidance of faculty advisor. May be elected once or twice, maximum credit allowed is 3 semester hours. 1 - 3 sh.

Prerequisites: Completion of 12 semester hours in this graduate program; instructor's permission.

CHEM598: Graduate Literature Search (2 hours independent study)

Development of and investigation of a topic from the current chemical literature. Selection and refinement of a topic. Collection and preparation of resources and materials and development of an outline in preparation of writing a literature report and giving a formal seminar on the literature search. This course cannot be taken by students electing the Research/Thesis option for their graduate program. This course may be repeated once for a maximum of 2 credits. 1 sh.

Prerequisites: Completion of 18 semester hours of 500-level courses in the graduate program.

CHEM599: Graduate Seminar (1 hour lecture)

An individual, non-experimental investigation and a formal presentation of scientific literature. 1 sh.

Prerequisites: CHEM 598.

CHEM698: Master's Thesis

Independent research project done under faculty advisement. Students must follow the MSU Thesis Guidelines, which may be obtained from the Graduate School. Students should take CHEM 699 if they don't complete CHEM 698 within the semester. 3 sh.

Prerequisites: Departmental approval.