- Science Hall 120
- 973 655-7982
- Not Available
- BA:Boston University
- MPhil:The City University of New York
- PhD:The City University of New York
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Professor, Biology and Molecular Biology
Part-Time Employee, The Center for Career Services and Cooperative Education
Dr. Halaby is also an Undergraduate Academic Advisor in the Department.
- Monday 1:00 pm - 3:00 pm
- Wednesday 1:00 pm - 2:00 pm
Effect of triptolide on protein expression.
We are investigating triptolide's ability to up- or down-regulate the protein expression levels of pro-apoptotic proteins, including caspases and PARP, in human breast and prostate cancer cells.
Lysosomes contain approximately 50 degradative enzymes that have the capability of digesting all of the molecules of a cell. We hypothesize that triptolide modulates lysosomal membrane permeability in such a way that it results in the release of the lysosomal enzymes, such as cathepsin B, into the cytosol. Our preliminary data indicates that this triptolide induces lysosomal-mediated apoptosis in MCF-7 breast and DU-145 prostate cancer cells.
We are working with a normal human mammary cell line, HuMEC cells, to determine the effects of triptolide on normal breast cells and establish a control cell line for comparison studies.