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Johannes Schelvis

Chairperson, Chemistry and Biochemistry

Office:
Richardson Hall
Email:
schelvisj@montclair.edu
Phone:
973-655-3301
Degrees:
BS, Vrije University (Netherlands)
PhD, University of Leiden
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Specialization

Repair of UV-damaged DNA by DNA photolyase and cryptochrome (single-strand DNA photolyase).
Antibiotic activation and resistance in KatG, the catalase-peroxidase of Mycobacterium tuberculosis.

Resume/CV

Office Hours

Fall

Monday
4:00 pm - 5:00 pm
Tuesday
3:00 pm - 4:00 pm
Thursday
11:30 am - 12:30 pm

Spring

Monday
1:00 pm - 2:00 pm
Tuesday
8:00 am - 9:00 am
Thursday
1:30 pm - 2:30 pm

Research Projects

Characterization of damage in DNA that is induced by UV-light

The exposure of cells to solar light, especially UV-A through UV-C light induces damage in DNA. This damage is mainly the dimerization of adjacent pyrimidine bases (cytidine and thymidine) in DNA. In this project, we are interested in characterizing these dimers by applying various spectroscopic techniques such as NMR, UV-vis absorption, Raman, and FT-IR spectroscopy. The spectroscopic methods are complemented with computational chemistry to obtain a better understanding of the spectroscopic data. Since the irradiation of DNA and DNA bases in solution with UV-light results in the formation of several photoproducts, we also use HPLC to purify the photodimers of interest. Besides studying small strands of DNA, we also investigate the nucleobases and nucleotides in solution.

Characterization of the interaction of the DNA-repair enzyme photolyase with damaged DNA

Characterization of the DNA-repair mechanism of the DNA-repair enzyme photolyase

Characterization of the structure-function realtionships in the blue-light photoreceptors photolyas, cryptochrome, and cryptochrome-DASH