Dr. DeSilva’s research focuses on supramolecular systems that utilize photoinduced electron transfer (PET) as a means of translating a molecular recognition event into an optical signal. The interest is in designing new molecules that allow the manipulation of several PET processes with multiple cation binding events.
Dr. Dyer’s research involves plant enzymology and molecular biology with a focus on the role of thiolases and cryptochromes. Techniques include bioinformatics, cloning, expression, purification and biochemical characterization. Collaborations with other groups involve work on elucidating structure and function relationships with these proteins.
Dr. Eshuis uses computational chemistry to understand the relationship between molecular structure of catalysts and their catalytic activity with emphasis on the role played by weak, non-covalent interactions. The research focuses on alkane metathesis and development of new quantum chemistry methods to get more accurate and efficient ways to describe molecules.
Dr. Gindt’s research interest is the mechanism by which DNA repair enzymes recognize damaged DNA bases with emphasis on DNA photolyase, which recognizes and repairs UV-damaged DNA bases. She has also interest in DNA repair at extreme temperatures. Her laboratory uses biophysical chemistry techniques including isothermal titration calorimetry, spectroelectrochemistry, and fluorescence spectroscopy.
Dr. Goodey’s lab conducts research in three areas that fall under the umbrella of understanding the structure and function of enzymes: Theme 1: The role of allosteric residues in drug binding; Theme 2: Use of phylogenetics to predict ligand-target interactions to repurpose drugs; and Theme 3: Understanding the biochemistry of heavy metal contaminated soil.
Dr. Hou’s research focusses on chemical methods to functionalize graphene oxide to develop novel electrode materials to design bio-sensors to detect dopamine and to support platinum nanoparticles substrates for fuel cell applications. Applications of graphene oxide are also developed for heavy metal removal from the environment.
Dr. Humphrey’s research work focuses on the synthesis and characterization of electron transfer molecules. The molecules can be organic, inorganic, organometallic or polymeric. Such molecules have application in photocells, batteries, and cyclic electron transfer processes.
Organic synthesis of heterocyclic compounds modified by attachment to ionic liquids. Applications include fluorescent sensors, kinase inhibitors, and antitumor agents. Research involves synthesis, separations, and analysis.
The current research is focused on a computational study of the steric and electronic contributions to structure and energy of α- and β-D-Glucopyanose. We are attempting to evaluate the degree to which electronic interactions and steric factors contribute to the stability of the structures and the conformational energy.
Dr. Konas conducts research in organic and bioorganic chemistry. He is primarily focused on the synthesis of compounds that are designed to be used as enzyme inhibitors and other kinds of biological tools and probes.
The Rotella laboratory is actively engaged in medicinal chemistry and drug discovery research. We use synthetic organic chemistry to prepare new molecules for biological testing as enzyme inhibitors, antiviral, neuroprotective and anticancer agents. We collaborate to study these molecules and use this information to prepare more potent, drug like compounds.
Dr. Schelvis uses laser based techniques such as Raman spectroscopy and time-resolved absorption spectroscopy to study enzymatic reactions, enzyme-substrate and protein-DNA interactions, and the transfer of electrons and protons in proteins. The DNA repair enzyme DNA photolyase and its interaction with UV-damaged DNA are of current interest.
Research is focused on the biochemistry of protein kinases. One major interest is the development of inhibitors of parasitic protein kinases as probes for studying the role of these enzymes in protecting parasites from immune-mediated rejection by the host and as potential therapeutic agents. A second area of investigation is the role of protein kinases in tumorigenesis.
The Talaga Lab studies amyloid formation mechanisms. Amyloid is an aggregated form of protein that accumulates in Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, Spongiform Encephalopathies and others. Our approaches include single molecule fluorescence lifetime, solid state nanopores, electrochemical impedance spectroscopy, interfacial effects on proteins, novel methods of global data analysis, and theory in support thereof.
Preparation and crystallographic study of coordination compounds with ligands that contain hydrogen bonding groups and reparation and characterization of quasiracemates containing transition metal complexes.